An early penalty by Alexis Mac Allister and a Darwin Nunez brace helped Liverpool to thrash Sparta Prague 5-1.
Antoine Griezmann and Samuel Lino scored in each half to give Atletico Madrid a 2-0 win over Lazio on Wednesday that secured them top spot in Champions League Group E, the first time since 2016 that they had reached the knockouts as group winners.
Newcastle United registered a 2-0 home win over Chelsea on Sunday that moves the Magpies a step closer to Champions League football next season.
Holders Manchester City will take on RB Leipzig, Red Star Belgrade and Young Boys in Group G.
Manchester United needed an extra-time winner from Marcus Rashford to defeat Anderlecht 2-1 at Old Trafford on Thursday and move into the last four of the Europa League with a 3-2 aggregate victory.
It is the first time since 1989-90 that Manchester United have lost 10 of their first 22 games of the league season.
United captain Jesse Lingard fired them ahead in the 10th minute with a fizzing low shot from 20 metres before Dmitri Shomko and a Di'Shon Bernard own goal turned the match on its head shortly after half-time.
Rubin Kazan, Udinese, Bruges and AZ Alkmaar qualified for the Europa league knock-out stages on Thursday and will go into the draw for the round of 32 with big guns Manchester United and Manchester City after their Champions League elimination.
Sevilla conjured up a dazzling comeback to clinch a record third successive Europa League title on Wednesday, flooring Liverpool with a 3-1 victory that showed why the Spanish side have become masters of Europe's second-tier competition.
West Ham United, reduced to 10 men after defender James Tomkins was sent off in the first half, won 5-3 in a penalty shootout against Maltese Cup winners Birkirkara to scrape into the Europa League third qualifying round on Thursday.
Real Madrid fight back to beat Mallorca and put Barca party on hold
IMAGES from Premier League matches played on Sunday.
Manchester United's Rasmus Hojlund and Alejandro Garnacho ended goal droughts and Bruno Fernandes scored again to earn a 3-0 win at struggling Leicester City.
Shakhtar dominated possession as expected but were toothless up front and Inter opened the scoring with their first chance after 19 minutes.
Kiev's Olympic stadium will host the final of the 2018 Champions League, the first final of Europe's top club competition to be held in Ukraine, UEFA said on Thursday.
Portuguese trio Porto, Benfica and Braga reached the Europa League semi-finals in contrasting styles as Europe's second-string club competition produced another goal feast on Thursday.
Tottenham have not won any silverware since they beat Chelsea in the 2008 League Cup final.
Barcelona have reached the semis only once since winning the Champions League in 2014-15.
Florian Thauvin headed in Payet's free kick after 15 minutes and Clinton Njie calmly slotted home in the 63rd to put Marseille in the driving seat against the Austrian champions.
With Crystal Palace dangerously close to being relegated, manager Patrick Vieira was sacked after 20 months in charge.
Atletico Madrid and Athletic Bilbao should serve up a Europa League final to remember on Wednesday and remind the continent that Spain is not just about Real Madrid or Barcelona.
Sevilla's Kevin Gameiro grabbed a late equaliser in a 2-2 draw at Zenit St Petersburg on Thursday to send the Europa League holders into the semi-finals after woeful goalkeeping had threatened to ruin their night.
Arsene Wenger's team look likely to return to Europe's most prestigious competition next season.
Several records and milestones were set after Real Madrid beat Liverpool 3-1 in the Champions League final on Saturday. With the victory Real became the first team to win three straight titles in the Champions League era.
Spain may have an iron grip on Europe's club competitions but the English Premier League is the dominant power when it comes to the number of players competing at Euro 2016. Spain have won the last two European championships and La Liga clubs have claimed Europe's major club trophies, the Champions League and Europa League, for the last three seasons. Yet a quarter of the 552 players going to Euro 2016 play in the English leagues, nearly four times as many as those from La Liga, according to figures from Grosvenor Casinos.
The three Premier League and three La Liga clubs in the last eight avoided each other, with Manchester City up against Atletico Madrid and Liverpool to face Portuguese side Benfica.
Porto's Radamel Falcao scored a hat-trick to help the newly-crowned Portuguese champions thrash Spartak Moscow 5-1 as goals flowed and South American players shone in Europa League quarter-final first leg ties on Thursday.
A summary of Sunday's action in the Premier League.
Mohamed Salah's early penalty in the return match on Thursday gave Liverpool a 1-0 victory in Italy but Klopp's side went out 3-1 on aggregate.
Five-times European champions Liverpool survived a late scare to move into the last 32 of the Europa League with a 1-0 win over Italian side Udinese on Thursday.
Runaway Premier League leaders Manchester City will play Borussia Dortmund with the winners to face either Bayern or PSG in the semi-finals.
Images from UEFA Champions League matches played on Wednesday.
Liverpool boss Juergen Klopp has said his team will be 'on fire' for the Champions League final
'We created loads of chances in our seven (Premier League) games but we have to step up.'
The race for Premier League places in next season's Europa League warmed up on Sunday when Aston Villa and Everton fought out a thrilling 3-3 draw and Fulham came from behind to win 3-1 at Manchester City.
Romanians Astra handed West Ham United their first competitive defeat at the London Stadium as Slaven Bilic's team were beaten in the Europa League playoffs on Thursday.
Tottenham Hotspur trounced a sorry Inter Milan 3-0 in the Europa League on Thursday while last year's European champions Chelsea were humbled 1-0 by Steaua Bucharest after being stung by a Raul Rusescu penalty.
Fernando Torres left Chelsea fans wondering if they would ever see the striker who once terrorised defences after another forlorn performance as they limped into the last 16 of the Europa League on Thursday.
Ajax keeper Remko Pasveer made five saves and scored on his own attempt to help the hosts win the shootout as Dutch international Brian Brobbey missed two penalties.
Lazio have been fined 40,000 euros for racist behaviour by their fans during the Europa League tie at Tottenham Hotspur last month, UEFA said on Thursday.
